Provider records sourced from NPPES (CMS National Plan & Provider Enumeration System). Data current as of October 4, 2026.
NPIDirectory

Dr. Karen Melinda Isaacs, MD

Individual provider Family Medicine Physician · NPI 1457589533

Dr. Karen Melinda Isaacs, MD is registered under Family Practice in Greer, South Carolina. Graduated from Wake Forest University School of Medicine in 2009, 17 years ago. Practices with Prisma Health University Medical Group, a 2,446-clinician group, works from 2 locations and accepts Medicare assignment. Licensed in North Carolina and South Carolina.

Years since qualifying
17
Trained at
Wake Forest University School of Medicine
Licensed in
NC, SC
In the registry since
2009
Specialties on file
2
What do these letters mean?
MD — Doctor of Medicine
A physician who completed allopathic medical school.

See every abbreviation used in this directory →

Claim this listing Report a problem Suggest an edit

Practice location Address checks out

109 Physicians Dr
Greer, SC 29650-2446
Phone: (864) 797-9150
Fax: (864) 797-9155
Show map & directions

Directions in Google Maps · Apple Maps · OpenStreetMap

Pin is approximate — placed at the ZIP-code centre, not the exact door.

Additional practice locations (1)

  • 2523 Delaney Ave, Wilmington, NC 28403-6003 — (910) 772-9202

Specialties & licences

Family Medicine Physician (primary) Taxonomy 207Q00000X · Licence 93966 (SC)
Family Medicine Physician Taxonomy 207Q00000X · Licence 201101212 (NC)

Record details

NPI number1457589533
Entity typeIndividual (Type 1)
GenderFemale
Credentials MD
Sole proprietorNo
NPI enumeratedJune 26, 2009
Last updated in NPPESJune 23, 2025
Certification dateJune 23, 2025

Medicare enrollment

From the CMS Doctors & Clinicians file — this clinician is enrolled in Medicare.

Medicare specialtyFAMILY PRACTICE
Medical schoolWAKE FOREST UNIVERSITY SCHOOL OF MEDICINE
Graduated 2009 (17 years in practice)
Group practice Prisma Health University Medical Group — 2446 clinicians
Accepts Medicare assignment Yes — accepts the Medicare-approved amount

Medicare patients and services, 2024

From the CMS Medicare Physician & Other Practitioners file for calendar year 2024. It counts Original Medicare patients only, so a practice that mostly sees Medicare Advantage or privately insured patients looks smaller here than it is.

Medicare patients392
Services billed 986 a service is one billed item, such as a visit, a test or a procedure
Average patient age74

Dollar amounts are not shown. What Medicare pays a practice is gross billings, before staff, premises and tax and including the cost of any drugs it administers, so it is not what a clinician earns.

Payments from drug and device companies, 2025

Drug and device makers are required by federal law (the Physician Payments Sunshine Act) to report what they pay or give to clinicians, and CMS publishes the reports as Open Payments. This is the 2025 program year. A report is a record of a payment, not an allegation of anything, and many are small items such as meals. Only general payments are listed here; research payments and ownership or investment interests are reported separately by CMS and are not shown.

Food and Beverage $26 1 payment · a meal or drink at a meeting or visit, not a fee

Each amount is the sum of what companies reported for that kind of payment in 2025, rounded to the dollar. Not all of it is income to the clinician: a meal is not a fee, a charitable contribution goes to a charity, and a royalty or an acquisition payment is not a salary.

Check a report, or dispute one, at the source in CMS’s own tool, Open Payments. Corrections go through CMS’s dispute process. This site removes a home address on request and asks for no proof, because that is privacy; it will not remove an accurate payment report on request, because that is a statutory public disclosure.

Practises at

Facilities the CMS Facility Affiliation file lists for this clinician. Those with a page here are linked.

Colleagues at Prisma Health University Medical Group

Clinicians the CMS Doctors & Clinicians file lists under the same group practice. CMS counts 2446 clinicians in the practice; 12 are shown here.

Other providers in Greer